Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire

Author:

von Borstel Anouk1ORCID,Chevour Priyanka1ORCID,Arsovski Daniel1ORCID,Krol Jelte M. M.23,Howson Lauren J.1ORCID,Berry Andrea A.4ORCID,Day Cheryl L.5ORCID,Ogongo Paul67ORCID,Ernst Joel D.6ORCID,Nomicos Effie Y. H.8,Boddey Justin A.23ORCID,Giles Edward M.9ORCID,Rossjohn Jamie11011ORCID,Traore Boubacar12,Lyke Kirsten E.4,Williamson Kim C.13ORCID,Crompton Peter D.14ORCID,Davey Martin S.1ORCID

Affiliation:

1. Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

2. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

3. University of Melbourne, Melbourne, Victoria 3010, Australia.

4. Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.

5. Department of Microbiology and Immunology, Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.

6. Division of Experimental Medicine, Department of Medicine, UCSF School of Medicine, San Francisco, CA, USA.

7. Department of Tropical and Infectious Diseases, Institute of Primate Research, National Museums of Kenya, P.O Box 24481-00502, Nairobi, Kenya.

8. Parasitology and International Programs Branch, Division of Microbiology and Infectious Diseases, NIAID, NIH, Bethesda, MD, USA.

9. Department of Paediatrics, Monash University, and Centre for Innate Immunity and Infectious Disease, Hudson Institute of Medicine, Clayton, Victoria 3168, Australia.

10. Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria 3800, Australia.

11. Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, CF14 4XN Cardiff, UK.

12. Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, International Center of Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.

13. Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

14. Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, USA.

Abstract

Malaria drives the adaptive differentiation of the human γδ T cell repertoire.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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