Transitional B cell cytokines predict renal allograft outcomes

Author:

Cherukuri Aravind12ORCID,Salama Alan D.3ORCID,Mehta Rajil12ORCID,Mohib Kanishka1ORCID,Zheng Leting14ORCID,Magee Ciara3ORCID,Harber Mark3ORCID,Stauss Hans5ORCID,Baker Richard J.6ORCID,Tevar Amit1ORCID,Landsittel Douglas17ORCID,Lakkis Fadi G.128ORCID,Hariharan Sundaram12ORCID,Rothstein David M.128ORCID

Affiliation:

1. Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2. Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

3. University College of London Department of Renal Medicine, Royal Free Hospital, London NW3 2QG, UK.

4. Department of Rheumatology and Immunology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.

5. UCL Institute of Immunity and Transplantation, Royal Free Hospital, London NW3 2QG, UK.

6. Renal Unit, St. James’s University Hospital, Leeds LS9 7TF, UK.

7. Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15206, USA.

8. Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

A low transitional-1 B cell IL-10/TNFα ratio predicts rejection and supports preemptive intervention for patients after kidney transplantation.

Funder

National Institutes of Health

AMERICAN SOCIETY OF TRANSPLANTATION

National Institute for Health Research

Roche Organ Transplant Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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