Prosaposin mediates inflammation in atherosclerosis-Reference-Cited by-同舟云学术

Prosaposin mediates inflammation in atherosclerosis

Published:2021-03-10 Issue:584 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

van Leent Mandy M. T.¹²^ORCID,Beldman Thijs J.²³^ORCID,Toner Yohana C.¹^ORCID,Lameijer Marnix A.¹²,Rother Nils⁴^ORCID,Bekkering Siroon³^ORCID,Teunissen Abraham J. P.¹^ORCID,Zhou Xianxiao⁵^ORCID,van der Meel Roy⁶^ORCID,Malkus Joost¹^ORCID,Nauta Sheqouia A.¹^ORCID,Klein Emma D.¹,Fay Francois¹⁷^ORCID,Sanchez-Gaytan Brenda L.¹⁸^ORCID,Pérez-Medina Carlos¹⁹^ORCID,Kluza Ewelina⁶^ORCID,Ye Yu-Xiang¹⁰¹¹,Wojtkiewicz Gregory¹⁰^ORCID,Fisher Edward A.¹²^ORCID,Swirski Filip K.¹⁰,Nahrendorf Matthias¹⁰^ORCID,Zhang Bin⁵^ORCID,Li Yang³¹³^ORCID,Zhang Bowen¹³^ORCID,Joosten Leo A. B.³¹⁴,Pasterkamp Gerard¹⁵,Boltjes Arjan¹⁵^ORCID,Fayad Zahi A.¹^ORCID,Lutgens Esther²¹⁶¹⁷^ORCID,Netea Mihai G.³¹⁸,Riksen Niels P.³^ORCID,Mulder Willem J. M.¹³⁶¹⁹^ORCID,Duivenvoorden Raphaël¹⁴^ORCID

Affiliation:

1. Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

2. Experimetal Vascular Biology, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, 1105 AZ Amsterdam, Netherlands.

3. Department of Internal Medicine and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

4. Department of Nephrology and Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.

5. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

6. Department of Chemical Biology, Eindhoven University of Technology, 5612 AZ Eindhoven, Netherlands.

7. Institut Galien Paris-Saclay, Faculté de Pharmacie, CNRS, Université Paris-Saclay, 92 296 Châtenay-Malabry, France.

8. Chemistry Center, Science Institute, Meritorious Autonomous University of Puebla, Puebla 72570, Mexico.

9. Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.

10. Center for Systems Biology, Massachusetts General Hospital Research Institute and Department of Radiology, Harvard Medical School, Boston, MA 02114, USA.

11. Department of Diagnostic and Interventional Radiology, University Hospitals Tuebingen, 72076 Tuebingen, Germany.

12. Department of Medicine (Cardiology) and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, NYU School of Medicine, New York, NY 10016, USA.

13. Centre for Individualised Infection Medicine (CiiM) and TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), 30625 Hannover, Germany.

14. Department of Medical Genetics, University of Medicine and Pharmacy, Iuliu Haţieganu, Cluj-Napoca 400000, Romania.

15. Central Diagnostics Laboratory, Division Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.

16. Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians Universität, 80331 Munich, Germany.

17. German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, 80539 Munich, Germany.

18. Department for Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, 53127 Bonn, Germany.

19. Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Abstract

Prosaposin mediates inflammation in experimental and human atherosclerosis and is associated with cellular metabolism and mTOR signaling.

Funder

National Institutes of Health

Teikyo University School of Medicine

National Heart Foundation of Australia

H2020 European Research Council

European Research Council