Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson’s disease

Author:

Morawska Marta M.12ORCID,Moreira Carlos G.13ORCID,Ginde Varun R.1,Valko Philipp O.1ORCID,Weiss Tobias1ORCID,Büchele Fabian1,Imbach Lukas L.1ORCID,Masneuf Sophie1,Kollarik Sedef12ORCID,Prymaczok Natalia4,Gerez Juan A.4,Riek Roland4,Baumann Christian R.125ORCID,Noain Daniela125ORCID

Affiliation:

1. Department of Neurology, University Hospital Zurich (USZ), Frauenklinikstrasse 26, Zurich 8091, Switzerland.

2. University of Zurich (UZH), Neuroscience Center Zurich (ZNZ), Winterthurerstrasse 190, Zurich 8057, Switzerland.

3. ETH Zurich, Neuroscience Center Zurich (ZNZ), Winterthurerstrasse 190, Zurich 8057, Switzerland.

4. ETH Zurich, Laboratory of Physical Chemistry, Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 2, Zurich 8093, Switzerland.

5. Center of Competence Sleep and Health Zurich, University of Zurich, Frauenklinikstrasse 26, Zurich 8091, Switzerland.

Abstract

Slow-wave modulation alters synuclein accumulation and regulates proteostatic pathways in Parkinson’s disease mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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