Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses

Author:

Bordt Evan A.1ORCID,Shook Lydia L.23,Atyeo Caroline45ORCID,Pullen Krista M.6ORCID,De Guzman Rose M.23ORCID,Meinsohn Marie-Charlotte7,Chauvin Maeva7,Fischinger Stephanie4ORCID,Yockey Laura J.28ORCID,James Kaitlyn2,Lima Rosiane9,Yonker Lael M.9ORCID,Fasano Alessio910ORCID,Brigida Sara23,Bebell Lisa M.8,Roberts Drucilla J.11ORCID,Pépin David7ORCID,Huh Jun R.1213,Bilbo Staci D.114,Li Jonathan Z.15ORCID,Kaimal Anjali2ORCID,Schust Danny J.16ORCID,Gray Kathryn J.17ORCID,Lauffenburger Douglas6ORCID,Alter Galit4ORCID,Edlow Andrea G.23ORCID

Affiliation:

1. Department of Pediatrics, Lurie Center for Autism, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

2. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

3. Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

4. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.

5. PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA 02115, USA.

6. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

7. Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

8. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

9. Mucosal Immunology and Biology Research Center, Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02129, USA.

10. European Biomedical Research Institute of Salerno (EBRIS), Salerno, Italy.

11. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

12. Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.

13. Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA.

14. Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA.

15. Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

16. Department of Obstetrics, Gynecology, and Women’s Health, University of Missouri, Columbia, MO 65201, USA.

17. Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Maternal SARS-CoV-2 infection drives sexually dimorphic placental immune responses and reduces SARS-CoV-2–specific antibody transfer to male fetuses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3