Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant-Reference-Cited by-同舟云学术

Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant

Published:2013-01-02 Issue:166 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Al-Mashhadi Rozh H.¹,Sørensen Charlotte B.²,Kragh Peter M.³,Christoffersen Christina⁴,Mortensen Martin B.¹,Tolbod Lars P.⁵,Thim Troels¹,Du Yutao³,Li Juan³,Liu Ying³,Moldt Brian²,Schmidt Mette⁶,Vajta Gabor³⁷,Larsen Torben³,Purup Stig³,Bolund Lars²⁸,Nielsen Lars B.⁴⁹,Callesen Henrik³,Falk Erling¹,Mikkelsen Jacob Giehm²,Bentzon Jacob F.¹

Affiliation:

1. Department of Cardiology, Aarhus University Hospital, and Department of Clinical Medicine, Aarhus University, Brendstrupgaardsvej 100, DK-8200 Aarhus N, Denmark.

2. Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 3, Building 1230, DK-8000 Aarhus C, Denmark.

3. Department of Animal Science, Aarhus University, Blichers Allé 20, DK-8830 Tjele, Denmark.

4. Department of Clinical Biochemistry, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

5. Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, DK-8200 Aarhus N, Denmark.

6. Department of Large Animal Sciences, University of Copenhagen, Dyrlægevej 68, DK-1870 Frederiksberg C, Denmark.

7. Central Queensland University, Bruce Highway, Rockhampton, Queensland 4702, Australia.

8. BGI (HuaDa JiYin), BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China.

9. Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark.

Abstract

A transgenic pig model of familial hypercholesterolemia can be used for translational atherosclerosis research.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

1. Progress and challenges in translating the biology of atherosclerosis

2. Evidence Mandating Earlier and More Aggressive Treatment of Hypercholesterolemia

3. Why not screen for subclinical atherosclerosis?

4. Atherosclerosis Drug Development in Jeopardy: The Need for Predictive Biomarkers of Treatment Response

5. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial

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