RNA-Based Gene Therapy for HIV with Lentiviral Vector–Modified CD34 + Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

Author:

DiGiusto David L.1,Krishnan Amrita1,Li Lijing1,Li Haitang2,Li Shirley3,Rao Anitha1,Mi Shu4,Yam Priscilla3,Stinson Sherri5,Kalos Michael6,Alvarnas Joseph1,Lacey Simon F.4,Yee Jiing-Kuan3,Li Mingjie7,Couture Larry38,Hsu David8,Forman Stephen J.1,Rossi John J.2,Zaia John A.3

Affiliation:

1. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.

2. Department of Molecular and Cellular Biology, City of Hope, Duarte, CA 91010, USA.

3. Department of Virology, City of Hope, Duarte, CA 91010, USA.

4. Clinical Immunobiology Correlative Studies Laboratory, City of Hope, Duarte, CA 91010, USA.

5. General Clinical Research Center, City of Hope, Duarte, CA 91010, USA.

6. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

7. Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

8. Center for Applied Technology Development, City of Hope, Duarte, CA 91010, USA.

Abstract

Transfected stem cells transplanted into patients with HIV infection resulted in sustained RNA expression of introduced genes in blood cells for up to 2 years.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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