RNA-Based Gene Therapy for HIV with Lentiviral Vector–Modified CD34 + Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma-Reference-Cited by-同舟云学术

RNA-Based Gene Therapy for HIV with Lentiviral Vector–Modified CD34 + Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

Published:2010-06-16 Issue:36 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

DiGiusto David L.¹,Krishnan Amrita¹,Li Lijing¹,Li Haitang²,Li Shirley³,Rao Anitha¹,Mi Shu⁴,Yam Priscilla³,Stinson Sherri⁵,Kalos Michael⁶,Alvarnas Joseph¹,Lacey Simon F.⁴,Yee Jiing-Kuan³,Li Mingjie⁷,Couture Larry³⁸,Hsu David⁸,Forman Stephen J.¹,Rossi John J.²,Zaia John A.³

Affiliation:

1. Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.

2. Department of Molecular and Cellular Biology, City of Hope, Duarte, CA 91010, USA.

3. Department of Virology, City of Hope, Duarte, CA 91010, USA.

4. Clinical Immunobiology Correlative Studies Laboratory, City of Hope, Duarte, CA 91010, USA.

5. General Clinical Research Center, City of Hope, Duarte, CA 91010, USA.

6. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

7. Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

8. Center for Applied Technology Development, City of Hope, Duarte, CA 91010, USA.

Abstract

Transfected stem cells transplanted into patients with HIV infection resulted in sustained RNA expression of introduced genes in blood cells for up to 2 years.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference42 articles.

1. The Challenge of Finding a Cure for HIV Infection

2. Distribution of Health Care Expenditures for HIV-Infected Patients

3. Intracellular immunization

4. Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

5. Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator.

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