Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system-Reference-Cited by-同舟云学术

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

Published:2014-09-24 Issue:255 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ebert Antje D.¹²³,Kodo Kazuki¹²,Liang Ping¹²³,Wu Haodi¹²³,Huber Bruno C.¹²,Riegler Johannes¹²,Churko Jared¹²⁴,Lee Jaecheol¹²³,de Almeida Patricia¹²,Lan Feng¹²³,Diecke Sebastian¹²³,Burridge Paul W.¹²³,Gold Joseph D.¹,Mochly-Rosen Daria⁴,Wu Joseph C.¹²³

Affiliation:

1. Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

4. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

The decrease of function in the ALDH2*2 genotype disrupts an important cardioprotective oxidative stress regulatory circuit, thus increasing cardiac cell death after ischemic insult.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

1. Disruption of the Coenzyme Binding Site and Dimer Interface Revealed in the Crystal Structure of Mitochondrial Aldehyde Dehydrogenase “Asian” Variant

2. Activation of Aldehyde Dehydrogenase-2 Reduces Ischemic Damage to the Heart

3. The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels

4. Aldehyde Dehydrogenase 2 Gene Is a Risk Factor for Myocardial Infarction in Japanese Men.

5. Genome-wide association study of coronary artery disease in the Japanese

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