Local Hydrogel Release of Recombinant TIMP-3 Attenuates Adverse Left Ventricular Remodeling After Experimental Myocardial Infarction-Reference-Cited by-同舟云学术

Local Hydrogel Release of Recombinant TIMP-3 Attenuates Adverse Left Ventricular Remodeling After Experimental Myocardial Infarction

Published:2014-02-12 Issue:223 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Eckhouse Shaina R.¹,Purcell Brendan P.²,McGarvey Jeremy R.³,Lobb David⁴,Logdon Christina B.⁴,Doviak Heather⁴,O’Neill Jason W.⁵,Shuman James A.⁴,Novack Craig P.⁴,Zellars Kia N.⁴,Pettaway Sara⁴,Black Roy A.⁵,Khakoo Aarif⁵,Lee TaeWeon⁵,Mukherjee Rupak¹,Gorman Joseph H.³,Gorman Robert C.³,Burdick Jason A.²,Spinale Francis G.⁴

Affiliation:

1. Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

2. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Gorman Cardiovascular Research Group, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Cardiovascular Translational Research Center, University of South Carolina School of Medicine and William Jennings Bryan Dorn Veteran Affairs Medical Center, Columbia, SC 29208, USA.

5. Amgen Incorporated, Seattle, WA 91320, USA.

Abstract

Delivery of a hydrogel providing sustained release of recombinant TIMP-3 attenuated adverse ventricular remodeling after myocardial infarction in pigs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference26 articles.

1. Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function

2. Myocardial Infarct Expansion and Matrix Metalloproteinase Inhibition

3. Dynamic Changes in Matrix Metalloprotienase Activity Within the Human Myocardial Interstitium During Myocardial Arrest and Reperfusion

4. Specific Temporal Profile of Matrix Metalloproteinase Release Occurs in Patients After Myocardial Infarction

5. Matrix Metalloproteinase Inhibitors

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