Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine-Reference-Cited by-同舟云学术

Molecular Mechanism for a Gateway Drug: Epigenetic Changes Initiated by Nicotine Prime Gene Expression by Cocaine

Published:2011-11-02 Issue:107 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Levine Amir¹²,Huang YanYou¹²,Drisaldi Bettina¹,Griffin Edmund A.²³,Pollak Daniela D.²,Xu Shiqin¹,Yin Deqi¹,Schaffran Christine²,Kandel Denise B.²³⁴,Kandel Eric R.¹²³⁵⁶

Affiliation:

1. Department of Neuroscience, College of Physicians and Surgeons, Columbia University, 1051 Riverside Drive, New York, NY 10032, USA.

2. New York State Psychiatric Institute, New York, NY 10032, USA.

3. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

4. Mailman School of Public Health, Columbia University, New York, NY 10032, USA.

5. Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

6. Kavli Institute for Brain Science, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Abstract

The finding that nicotine enhances the brain’s response to cocaine may explain how smoking acts as a gateway drug for this addictive stimulant.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference34 articles.

1. Stages in adolescent involvement in drug use

2. D. B. Kandel Stages and Pathways of Drug Involvement: Examining the Gateway Hypothesis (Cambridge Univ. Press Cambridge UK 2002) pp. 3–15.

3. Patterns of drug use from adolescence to young adulthood: II. Sequences of progression.

4. Substance Abuse and Mental Health Services Administration Office of Applied Studies National Survey on Drug Use and Health 2009 [Computer file] ICPSR29621-v1 Ann Arbor MI: Inter-university Consortium for Political and Social Research [distributor] 2010-11-16.

5. Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine

Cited by 238 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Histone Methyltransferase G9a Plays an Essential Role on Nicotine Preference in Zebrafish;Molecular Neurobiology;2024-01-30

2. Epigenetic mechanisms of nicotine dependence;Neuroscience & Biobehavioral Reviews;2024-01

3. BÜTÜNCÜL MÜDAHALEYİ İÇEREN ÖNLEYİCİ ÇALIŞMALARIN ÖĞRENCİLERDE MADDE BAĞIMLILIĞINA ETKİLERİ: PROSPEKTİF İZLEM ÇALIŞMASI;Uluslararası Anadolu Sosyal Bilimler Dergisi;2023-12-31

4. Epigenetic modification impacting brain functions: Effects of physical activity, micronutrients, caffeine, toxins, and addictive substances;Neurochemistry International;2023-12

5. Mechanisms of E-Cigarette Vape-Induced Epithelial Cell Damage;Cells;2023-10-31