Neural Stem Cell–Mediated Enzyme/Prodrug Therapy for Glioma: Preclinical Studies

Author:

Aboody Karen S.12,Najbauer Joseph1,Metz Marianne Z.1,D’Apuzzo Massimo3,Gutova Margarita1,Annala Alexander J.1,Synold Timothy W.4,Couture Larry A.5,Blanchard Suzette6,Moats Rex A.7,Garcia Elizabeth1,Aramburo Soraya1,Valenzuela Valerie V.1,Frank Richard T.1,Barish Michael E.1,Brown Christine E.8,Kim Seung U.9,Badie Behnam2,Portnow Jana10

Affiliation:

1. Department of Neurosciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

2. Division of Neurosurgery, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

3. Department of Pathology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

4. Department of Clinical and Molecular Pharmacology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

5. Center for Applied Technology Development, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

6. Division of Biostatistics, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

7. Department of Radiology, Children’s Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

8. Department of Cancer Immunotherapeutics and Tumor Immunology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

9. Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia V6T2B5, Canada.

10. Department of Medical Oncology and Experimental Therapeutics, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

Abstract

Neural stem cells home to gliomas in mice where they convert a prodrug to 5-fluorouracil, leading to tumor regression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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