Genetic Correction of PSA Values Using Sequence Variants Associated with PSA Levels

Author:

Gudmundsson Julius1,Besenbacher Soren1,Sulem Patrick1,Gudbjartsson Daniel F.1,Olafsson Isleifur2,Arinbjarnarson Sturla3,Agnarsson Bjarni A.24,Benediktsdottir Kristrun R.24,Isaksson Helgi J.2,Kostic Jelena P.1,Gudjonsson Sigurjon A.1,Stacey Simon N.1,Gylfason Arnaldur1,Sigurdsson Asgeir1,Holm Hilma1,Bjornsdottir Unnur S.4,Eyjolfsson Gudmundur I.5,Navarrete Sebastian6,Fuertes Fernando6,Garcia-Prats Maria D.7,Polo Eduardo8,Checherita Ionel A.9,Jinga Mariana9,Badea Paula10,Aben Katja K.1112,Schalken Jack A.13,van Oort Inge M.13,Sweep Fred C.14,Helfand Brian T.15,Davis Michael16,Donovan Jenny L.16,Hamdy Freddie C.17,Kristjansson Kristleifur1,Gulcher Jeffrey R.1,Masson Gisli1,Kong Augustine1,Catalona William J.15,Mayordomo Jose I.18,Geirsson Gudmundur2,Einarsson Gudmundur V.2,Barkardottir Rosa B.24,Jonsson Eirikur2,Jinga Viorel9,Mates Dana10,Kiemeney Lambertus A.111213,Neal David E.19,Thorsteinsdottir Unnur14,Rafnar Thorunn1,Stefansson Kari14

Affiliation:

1. deCODE genetics, IS-101 Reykjavik, Iceland.

2. Landspitali-University Hospital, IS-101 Reykjavik, Iceland.

3. Glaesibaer, Clinical Research Laboratory, IS-108 Reykjavik, Iceland.

4. Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.

5. The Laboratory in Mjodd, IS-109 Reykjavik, Iceland.

6. Division of Radiation Oncology, University Hospital, 50009 Zaragoza, Spain.

7. Division of Pathology, San Jorge General Hospital, 22004 Huesca, Spain.

8. Royo Villanova Hospital, 500014 Zaragoza, Spain.

9. University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.

10. National Institute of Public Health, 050463 Bucharest, Romania.

11. Comprehensive Cancer Center East, 6501 BG Nijmegen, Netherlands.

12. Department of Epidemiology, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands.

13. Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands.

14. Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands.

15. Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

16. School of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK.

17. Nuffield Department of Surgical Science, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

18. Division of Medical Oncology, University Hospital, 50009 Zaragoza, Spain.

19. Oncology Centre, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK.

Abstract

Sequence variants in the human genome are associated with serum levels of prostate-specific antigen.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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