Intratumoral injection of Clostridium novyi -NT spores induces antitumor responses

Author:

Roberts Nicholas J.1,Zhang Linping2,Janku Filip3,Collins Amanda2,Bai Ren-Yuan4,Staedtke Verena45,Rusk Anthony W.6,Tung David2,Miller Maria2,Roix Jeffrey2,Khanna Kristen V.6,Murthy Ravi7,Benjamin Robert S.8,Helgason Thorunn3,Szvalb Ariel D.9,Bird Justin E.10,Roy-Chowdhuri Sinchita11,Zhang Halle H.2,Qiao Yuan1,Karim Baktiar12,McDaniel Jennifer13,Elpiner Amanda14,Sahora Alexandra15,Lachowicz Joshua16,Phillips Brenda17,Turner Avenelle18,Klein Mary K.19,Post Gerald13,Diaz Luis A.120,Riggins Gregory J.4,Papadopoulos Nickolas1,Kinzler Kenneth W.1,Vogelstein Bert1,Bettegowda Chetan14,Huso David L.12,Varterasian Mary2,Saha Saurabh2,Zhou Shibin1

Affiliation:

1. The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute at The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.

2. BioMed Valley Discoveries Inc., 4520 Main Street, Kansas City, MO 64111, USA.

3. Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

4. Department of Neurosurgery, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

5. Department of Neurology, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

6. Animal Clinical Investigation LLC, 4926 Wisconsin Avenue, NW Washington, DC 20016, USA.

7. Department of Interventional Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

8. Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

9. Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

10. Department of Orthopedic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

11. Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

12. Department of Molecular and Comparative Pathobiology, The Johns Hopkins University, Baltimore, MD 21205, USA.

13. The Veterinary Cancer Center, 129 Glover Avenue, Norwalk, CT 06850, USA.

14. VCA Great Lakes Veterinary Specialists, 5035 Richmond Road, Bedford Heights, OH 44146, USA.

15. The Oncology Service, Friendship Hospital for Animals, 4105 Brandywine Street, NW, Washington, DC 20016, USA.

16. BluePearl Veterinary Partners, 410 West 55th Street, New York, NY 10019, USA.

17. Veterinary Specialty Hospital of San Diego, 10435 Sorrento Valley Road, San Diego, CA 92121, USA.

18. Veterinary Cancer Group of Los Angeles at City of Angels Veterinary Specialty Center, 9599 Jefferson Boulevard, Culver City, CA 90232, USA.

19. Southern Arizona Veterinary Specialty and Emergency Center, 141 East Fort Lowell, Tucson, AZ 85705, USA.

20. The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21231, USA.

Abstract

Clostridium novyi -NT targets aberrant tumor physiology and can produce a precise, robust, and reproducible antitumor response.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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