Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production-Reference-Cited by-同舟云学术

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Published:2014-07-02 Issue:243 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Gauvreau Gail M.¹,Harris Jeffrey M.²,Boulet Louis-Philippe³,Scheerens Heleen²,Fitzgerald J. Mark⁴,Putnam Wendy S.²,Cockcroft Donald W.⁵,Davis Beth E.⁵,Leigh Richard⁶,Zheng Yanan²,Dahlén Barbro⁷,Wang Yehong²,Maciuca Romeo²,Mayers Irvin⁸,Liao X. Charlene²,Wu Lawren C.²,Matthews John G.²,O’Byrne Paul M.¹

Affiliation:

1. McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

2. Genentech Inc., South San Francisco, CA 94080, USA.

3. Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec G1V 4G5, Canada.

4. University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.

5. University of Saskatchewan, Saskatoon, Saskatchewan S7N 0W8, Canada.

6. University of Calgary, Calgary, Alberta T2N 4Z6, Canada.

7. Karolinska University Hospital, Stockholm S-141 86, Sweden.

8. University of Alberta, Edmonton, Alberta T6G 2G3, Canada.

Abstract

A humanized monoclonal antibody that targets the membrane IgE B cell receptor was associated with improvements in asthmatic airway responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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