Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors-Reference-Cited by-同舟云学术

Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors

Published:2011-11-16 Issue:109 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cusumano Corinne K.¹²,Pinkner Jerome S.¹²,Han Zhenfu³,Greene Sarah E.¹²,Ford Bradley A.²⁴,Crowley Jan R.⁵,Henderson Jeffrey P.²⁵,Janetka James W.³,Hultgren Scott J.¹²

Affiliation:

1. Department of Molecular Microbiology and Microbial Pathogenesis, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

2. Center for Women’s Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.

4. Department of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Department of Internal Medicine (Infectious Diseases), Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Optimized mannoside compounds that block uropathogenic E. coli entry into bladder epithelium were effective in the treatment and prevention of urinary tract infections in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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