Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients

Author:

Russnes Hege G.123,Vollan Hans Kristian Moen134,Lingjærde Ole Christian5,Krasnitz Alexander6,Lundin Pär7,Naume Bjørn8,Sørlie Therese1,Borgen Elin2,Rye Inga H.2,Langerød Anita1,Chin Suet-Feung9,Teschendorff Andrew E.910,Stephens Philip J.11,Månér Susanne7,Schlichting Ellen4,Baumbusch Lars O.125,Kåresen Rolf4,Stratton Michael P.1112,Wigler Michael6,Caldas Carlos913,Zetterberg Anders7,Hicks James6,Børresen-Dale Anne-Lise13

Affiliation:

1. Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway.

2. Division of Pathology, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway.

3. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318 Oslo, Norway.

4. Department of Breast and Endocrine Surgery, Division of Surgery and Cancer, Oslo University Hospital, 0450 Oslo, Norway.

5. Biomedical Research Group, Department of Informatics, University of Oslo, P.O. Box 1080 Blindern, 0316 Oslo, Norway.

6. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

7. Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, SE-171 76 Stockholm, Sweden.

8. Department of Oncology, Division of Surgery and Cancer, Oslo University Hospital Radiumhospitalet, 0310 Oslo, Norway.

9. Breast Cancer Functional Genomics, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Li Ka-Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

10. UCL Cancer Institute, University College London, London WC1E 6BT, UK.

11. Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

12. Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

13. Cambridge Breast Unit, Addenbrookes Hospital and Cambridge National Institute for Health Research Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK.

Abstract

This study demonstrates the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that an objective score of genomic complexity can provide independent prognostic information in breast cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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