Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression-Reference-Cited by-同舟云学术

Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression

Published:2012-07-11 Issue:142 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Stallings-Mann Melody L.¹,Waldmann Jens¹²,Zhang Ying¹,Miller Erin¹,Gauthier Mona L.³,Visscher Daniel W.⁴,Downey Gregory P.⁵⁶⁷,Radisky Evette S.¹,Fields Alan P.¹,Radisky Derek C.¹

Affiliation:

1. Department of Cancer Biology, Mayo Clinic Cancer Center, Jacksonville, FL 32224, USA.

2. Department of Visceral, Thoracic, and Vascular Surgery, University Hospital Giessen and Marburg, Marburg, Baldingerstrasse 35043, Germany.

3. Campbell Family Institute for Cancer Research, Ontario Cancer Institute, Toronto, Ontario M5G 2C1, Canada.

4. Department of Anatomic Pathology, Mayo Clinic Cancer Center, Rochester, MN 55906, USA.

5. Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

6. Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA.

7. Integrated Department of Immunology, National Jewish Health and University of Colorado Denver, Aurora, CO 80045, USA.

Abstract

Rac1b mediates the matrix metalloproteinase–induced epithelial-mesenchymal transition in lung adenocarcinoma and is a potential therapeutic target in early-stage lung cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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