A Blood-Based Proteomic Classifier for the Molecular Characterization of Pulmonary Nodules

Author:

Li Xiao-jun1,Hayward Clive1,Fong Pui-Yee1,Dominguez Michel1,Hunsucker Stephen W.1,Lee Lik Wee1,McLean Matthew1,Law Scott1,Butler Heather1,Schirm Michael2,Gingras Olivier2,Lamontagne Julie2,Allard Rene2,Chelsky Daniel2,Price Nathan D.3,Lam Stephen4,Massion Pierre P.56,Pass Harvey7,Rom William N.8,Vachani Anil9,Fang Kenneth C.1,Hood Leroy3,Kearney Paul1

Affiliation:

1. Integrated Diagnostics, Seattle, WA 98109, USA.

2. Caprion Proteomics, Montreal, Quebec, H2X 3Y7 Canada.

3. Institute for Systems Biology, Seattle, WA 98109, USA.

4. Department of Pulmonary Medicine, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 4E6, Canada.

5. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

6. Thoracic Oncology Center, Vanderbilt Ingram Comprehensive Cancer Center, Nashville, TN 37232, USA.

7. Department of Cardiothoracic Surgery, New York University Langone Medical Center, New York, NY 10016, USA.

8. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

9. Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Systems biology and targeted mass spectrometry were combined to develop and validate a blood-based protein classifier for pulmonary nodules.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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