Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions-Reference-Cited by-同舟云学术

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

Published:2011-05-11 Issue:82 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Dombrowski Yvonne¹,Peric Mark¹,Koglin Sarah¹,Kammerbauer Claudia¹,Göß Christine¹,Anz David²,Simanski Maren³,Gläser Regine³,Harder Jürgen³,Hornung Veit⁴,Gallo Richard L.⁵,Ruzicka Thomas¹,Besch Robert¹,Schauber Jürgen¹

Affiliation:

1. Department of Dermatology and Allergy, Ludwig-Maximilian-University, 80337 Munich, Germany.

2. Division of Clinical Pharmacology, Ludwig-Maximilian-University, 80337 Munich, Germany.

3. Department of Dermatology, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

4. Institute of Clinical Chemistry and Pharmacology, University of Bonn, 53127 Bonn, Germany.

5. Department of Dermatology and Veterans Affairs San Diego Healthcare System, University of California, San Diego, CA 92093, USA.

Abstract

In psoriasis, cytosolic DNA in keratinocytes triggers maturation of the cytokine IL-1β via the AIM2 inflammasome.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference33 articles.

1. Psoriasis

2. Generation of pathogenic TH17 cells in the absence of TGF-β signalling

3. Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

4. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells

5. A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

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