Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis

Author:

Fletcher Anne L.1234,Elman Jessica S.5,Astarita Jillian12,Murray Ryan5,Saeidi Nima5,D’Rozario Joshua3,Knoblich Konstantin1,Brown Flavian D.12,Schildberg Frank A.12,Nieves Janice M.12,Heng Tracy S. P.3,Boyd Richard L.3,Turley Shannon J.12,Parekkadan Biju56

Affiliation:

1. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

2. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.

4. School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK.

5. Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, MA 02114, USA.

6. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Abstract

Infusion of lymph node–derived fibroblastic reticular cells into septic mice increases survival at late time points after disease onset.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference80 articles.

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2. Surviving the first hours in sepsis: getting the basics right (an intensivist's perspective)

3. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

4. M. J. Hall S. N. Williams C. J. DeFrances M. S. Golosinskiy Inpatient Care for Septicemia or Sepsis: A Challenge for Patients and Hospitals (National Center for Health Statistics Hyattsville MD 2011).

5. J. Ferlay H. R. Shin F. Bray D. Forman C. Mathers D. M. Parkin GLOBOCAN 2008 v.2.0. Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10; http://globocan.iarc.fr.

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