Pathway-Based Identification of Biomarkers for Targeted Therapeutics: Personalized Oncology with PI3K Pathway Inhibitors-Reference-Cited by-同舟云学术

Pathway-Based Identification of Biomarkers for Targeted Therapeutics: Personalized Oncology with PI3K Pathway Inhibitors

Published:2010-08-04 Issue:43 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Andersen Jannik N.¹,Sathyanarayanan Sriram¹,Di Bacco Alessandra¹,Chi An¹,Zhang Theresa¹,Chen Albert H.¹,Dolinski Brian¹,Kraus Manfred¹,Roberts Brian¹,Arthur William²,Klinghoffer Rich A.¹,Gargano Diana¹,Li Lixia¹,Feldman Igor¹,Lynch Bethany¹,Rush John³,Hendrickson Ronald C.⁴,Blume-Jensen Peter¹,Paweletz Cloud P.¹

Affiliation:

1. Merck Sharp & Dohme, Boston, MA 02115, USA.

2. Merck Sharp & Dohme, North Wales, PA 19454, USA.

3. Cell Signaling Technology, Danvers, MA 01923, USA.

4. Merck Sharp & Dohme, Rahway, NJ 07065, USA.

Abstract

Phosphorylation sites on proteins in the phosphatidylinositol 3-kinase pathway that are regulated by candidate drugs can serve as useful biomarkers to predict tumor sensitivity to AKT inhibitors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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