Intermittent Prophylaxis with Oral Truvada Protects Macaques from Rectal SHIV Infection

Author:

García-Lerma J. Gerardo1,Cong Mian-er1,Mitchell James1,Youngpairoj Ae S.1,Zheng Qi1,Masciotra Silvina1,Martin Amy1,Kuklenyik Zsuzsanna2,Holder Angela1,Lipscomb Jonathan1,Pau Chou-Pong1,Barr John R.2,Hanson Debra L.1,Otten Ron1,Paxton Lynn1,Folks Thomas M.13,Heneine Walid1

Affiliation:

1. Division of HIV/AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA.

2. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.

3. Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA.

Abstract

Treating monkeys with single doses of an antiretroviral drug before and after exposure to SHIV provides protection against infection, a schedule that may prove practical in humans.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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