A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome-Reference-Cited by-同舟云学术

A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome

Published:2012-03-07 Issue:124 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Shi Yichen¹,Kirwan Peter¹,Smith James¹,MacLean Glenn²,Orkin Stuart H.²,Livesey Frederick J.¹

Affiliation:

1. Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

2. Howard Hughes Medical Institute, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children’s Hospital Boston and Harvard Stem Cell Institute, Boston, MA 02115, USA.

Abstract

Cultured cerebral cortex neurons generated from human Down syndrome induced pluripotent stem cells rapidly develop Alzheimer’s disease pathologies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference38 articles.

1. Alzheimer's Disease

2. The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

3. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

4. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

5. Probing the Biology of Alzheimer's Disease in Mice

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