Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing-Reference-Cited by-同舟云学术

Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing

Published:2013-08-07 Issue:197 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hoang Margaret L.¹,Chen Chung-Hsin²,Sidorenko Viktoriya S.³,He Jian¹,Dickman Kathleen G.³⁴,Yun Byeong Hwa⁵,Moriya Masaaki³,Niknafs Noushin⁶,Douville Christopher⁶,Karchin Rachel⁶,Turesky Robert J.⁵,Pu Yeong-Shiau²,Vogelstein Bert¹,Papadopoulos Nickolas¹,Grollman Arthur P.³⁴,Kinzler Kenneth W.¹,Rosenquist Thomas A.³

Affiliation:

1. Ludwig Center for Cancer Genetics and Therapeutics and the Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA.

2. Department of Urology, National Taiwan University Hospital and College of Medicine, Taipei 10002, Taiwan.

3. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794, USA.

4. Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

5. Division of Environmental Health Sciences, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA.

6. Department of Biomedical Engineering, Institute for Computational Medicine, the Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract

The mutational signature of aristolochic acid exemplifies how genome-wide sequencing can be used to identify environmental exposures leading to cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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