A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques-Reference-Cited by-同舟云学术

A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques

Published:2011-08-03 Issue:94 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Garrone Pierre¹,Fluckiger Anne-Catherine¹,Mangeot Philippe E.¹,Gauthier Emmanuel²,Dupeyrot-Lacas Pia¹,Mancip Jimmy¹,Cangialosi Arnaud¹,Du Chéné Isaure¹,LeGrand Roger³,Mangeot Isabelle³,Lavillette Dimitri²,Bellier Bertrand⁴⁵⁶,Cosset François-Loic²,Tangy Frederic⁷,Klatzmann David⁴⁵⁶⁸,Dalba Charlotte¹⁹

Affiliation:

1. Epixis S.A., F-69007 Lyon, France.

2. Université de Lyon, Université Claude Bernard Lyon I, IFR128; INSERM U758; ENS de Lyon, F-69007 Lyon, France.

3. CEA, Service de Neurovirologie (DSV/DRM), CRSSA, Institut Paris-Sud sur les Cytokines, F-92260 Fontenay aux Roses, France.

4. Université Pierre et Marie Curie Paris 06, UMR7211, Immunology-Immunopathology-Immunotherapy (I3), F-75013 Paris, France.

5. CNRS, UMR7211, I3, F-75013 Paris, France.

6. INSERM, UMR_S959, I3, F-75013 Paris, France.

7. Unité de Génomique Virale et Vaccination, Department of Virology, Institut Pasteur, CNRS URA 3015, F-75015 Paris, France.

8. AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy, F-75013 Paris, France.

9. Epixis S.A., F-75013 Paris, France.

Abstract

Virus-like particles pseudotyped with heterologous viral envelopes stimulate broadly cross-neutralizing antibodies against HCV.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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