β-Catenin Promotes Colitis and Colon Cancer Through Imprinting of Proinflammatory Properties in T Cells-Reference-Cited by-同舟云学术

β-Catenin Promotes Colitis and Colon Cancer Through Imprinting of Proinflammatory Properties in T Cells

Published:2014-02-26 Issue:225 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Keerthivasan Shilpa¹,Aghajani Katayoun¹²,Dose Marei¹,Molinero Luciana¹,Khan Mohammad W.³⁴,Venkateswaran Vysak³,Weber Christopher⁵,Emmanuel Akinola Olumide¹,Sun Tianjao¹,Bentrem David J.⁶⁷,Mulcahy Mary⁸,Keshavarzian Ali⁹,Ramos Elena M.¹⁰,Blatner Nichole³,Khazaie Khashayarsha³,Gounari Fotini¹

Affiliation:

1. Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, USA.

2. Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA.

3. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

4. San Diego State University, San Diego, CA 92182, USA.

5. Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.

6. Department of Surgery, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair, Chicago, IL 60611, USA.

7. Jesse Brown VA Medical Center, 820 South Damen Avenue, Chicago, IL 60612, USA.

8. Department of Hematology/Oncology, Northwestern Medical Faculty Foundation, Chicago, IL 60611, USA.

9. Division of Digestive Diseases and Nutrition, Department of Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

10. Pathology Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA.

Abstract

Wnt/β-catenin signaling in T cells is activated during polyposis and colon cancer and drives inflammation and tumor growth by promoting expression of T H 17-associated genes including RORγt.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

2. An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

3. Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

4. Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

5. Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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