Inducing CTLA-4–Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation-Reference-Cited by-同舟云学术

Inducing CTLA-4–Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

Published:2010-02-03 Issue:17 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Poirier Nicolas¹,Azimzadeh Agnes M.²,Zhang Tianshu²,Dilek Nahzli¹,Mary Caroline³,Nguyen Bao²,Tillou Xavier¹,Wu Guosheng²,Reneaudin Karine⁴,Hervouet Jeremy¹,Martinet Bernard¹,Coulon Flora¹,Allain-Launay Emma¹,Karam Georges¹,Soulillou Jean-Paul¹,Pierson Richard N.²,Blancho Gilles¹,Vanhove Bernard¹

Affiliation:

1. INSERM U643, ITERT-Uro-Nephro, Centaure Network, CHU Nantes, 30 Bl J. Monnet, 44093 Nantes, France.

2. Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

3. TcL Pharma SAS, 44035 Nantes, France.

4. University of Nantes, UFR of Medicine, 44035 Nantes, France.

Abstract

An improved method of immunosuppression allows better immune function and prolongs the survival of transplanted organs in nonhuman primates.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.

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2. B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

3. CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells

4. Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

5. Ido expression by dendritic cells: tolerance and tryptophan catabolism

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