T Cell Receptor αβ Diversity Inversely Correlates with Pathogen-Specific Antibody Levels in Human Cytomegalovirus Infection-Reference-Cited by-同舟云学术

T Cell Receptor αβ Diversity Inversely Correlates with Pathogen-Specific Antibody Levels in Human Cytomegalovirus Infection

Published:2012-04-04 Issue:128 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wang George C.¹²,Dash Pradyot¹,McCullers Jonathan A.³,Doherty Peter C.²,Thomas Paul G.²

Affiliation:

1. Division of Geriatric Medicine and Gerontology, Biology of Healthy Aging Program, Johns Hopkins University School of Medicine, 5505 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

2. Department of Immunology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

3. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

Abstract

CD8 + T cell diversity may be more important than T cell abundance in limiting the negative consequences of cytomegalovirus persistence.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. Functional implications of T cell receptor diversity

2. Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

3. T-cell antigen receptor genes and T-cell recognition

4. Molecular Characterization of the Lymphoid V(D) J Recombination Activity

5. Direct Link Between mhc Polymorphism, T Cell Avidity, and Diversity in Immune Defense

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