Overlap and Effective Size of the Human CD8 + T Cell Receptor Repertoire-Reference-Cited by-同舟云学术

Overlap and Effective Size of the Human CD8 + T Cell Receptor Repertoire

Published:2010-09 Issue:47 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Robins Harlan S.¹,Srivastava Santosh K.¹,Campregher Paulo V.²,Turtle Cameron J.²,Andriesen Jessica¹,Riddell Stanley R.²,Carlson Christopher S.³,Warren Edus H.¹

Affiliation:

1. Program in Computational Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

2. Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

3. Program in Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

Deep sequencing of the T cell receptor repertoires of seven healthy adults reveals that the adaptive immune system is far less diverse than expected and the person-to-person overlap is thousands of times larger.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference14 articles.

1. T-cell antigen receptor genes and T-cell recognition

2. Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells

3. The molecular basis for public T-cell responses?

4. Efficient immune responses in mice lacking N-region diversity

5. Most α/β T Cell Receptor Diversity Is Due to Terminal Deoxynucleotidyl Transferase

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