Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABA A Receptors-Reference-Cited by-同舟云学术

Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABA A Receptors

Published:2012-11-21 Issue:161 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rye David B.¹,Bliwise Donald L.¹,Parker Kathy²,Trotti Lynn Marie¹,Saini Prabhjyot¹,Fairley Jacqueline¹,Freeman Amanda¹,Garcia Paul S.³⁴,Owens Michael J.⁵,Ritchie James C.⁶,Jenkins Andrew³⁷

Affiliation:

1. Department of Neurology, Program in Sleep, Emory University School of Medicine, Atlanta, GA 30322, USA.

2. Emory University School of Nursing, Atlanta, GA 30322, USA.

3. Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322, USA.

4. Anesthesiology and Research Divisions, Atlanta VA Medical Center, Atlanta, GA 30033, USA.

5. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.

6. Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.

7. Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

A component of cerebrospinal fluid in excessively sleepy people activates an inhibitory signaling pathway and mimics the actions of sedative-hypnotics.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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