Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging-Reference-Cited by-同舟云学术

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

Published:2011-10-26 Issue:106 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Osorio Fernando G.¹,Navarro Claire L.²,Cadiñanos Juan¹,López-Mejía Isabel C.³,Quirós Pedro M.¹,Bartoli Catherine²,Rivera José⁴,Tazi Jamal³,Guzmán Gabriela⁵,Varela Ignacio¹,Depetris Danielle²,de Carlos Félix⁶,Cobo Juan⁶,Andrés Vicente⁴,De Sandre-Giovannoli Annachiara²⁷,Freije José M. P.¹,Lévy Nicolas²⁷,López-Otín Carlos¹

Affiliation:

1. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.

2. Université de la Méditerranée, Inserm UMR_S 910, Faculté de Médecine de Marseille, 13385 Marseille cedex 05, France.

3. Institut de Génétique Moléculaire, UMR 5535 CNRS, 34293 Montpellier cedex 5, France.

4. Departamento de Epidemiología, Aterotrombosis e Imagen, Centro Nacional de Investigaciones Cardiovasculares, 28029 Madrid, Spain.

5. Servicio de Cardiología, Hospital Universitario La Paz, 28046 Madrid, Spain.

6. Departamento de Cirugía y Especialidades Médico-Quirúrgicas and Instituto Asturiano de Odontología, Universidad de Oviedo, 33006 Oviedo, Spain.

7. AP-HM, Département de Génétique Médicale, Hôpital d’Enfants de la Timone, 13385 Marseille cedex 05, France.

Abstract

Antisense oligonucleotides reverse premature aging and extend life span in mutant mice that mimic aberrant splicing in progeria patients.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

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