CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients-Reference-Cited by-同舟云学术

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

Published:2012-05-16 Issue:134 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rech Andrew J.¹,Mick Rosemarie²³,Martin Sunil¹⁴,Recio Adri¹,Aqui Nicole A.²⁵,Powell Daniel J.¹²⁵,Colligon Theresa A.¹,Trosko Jennifer A.¹,Leinbach Leah I.⁵,Pletcher Charles H.⁵,Tweed Carol K.²⁶,DeMichele Angela²⁶,Fox Kevin R.²⁶,Domchek Susan M.²⁶,Riley James L.¹²⁴,Vonderheide Robert H.¹²⁶

Affiliation:

1. Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

2. Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

3. Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

4. Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

5. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

6. Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Abstract

CD25 monoclonal antibody therapy rapidly and durably depletes T regs in cancer patients through a mechanism consistent with reprogramming.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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