Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD-Reference-Cited by-同舟云学术

Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD

Published:2013-06-05 Issue:188 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Andero Raül¹²,Brothers Shaun P.³,Jovanovic Tanja²,Chen Yen T.⁴,Salah-Uddin Hasib³,Cameron Michael⁵,Bannister Thomas D.⁴,Almli Lynn²,Stevens Jennifer S.²,Bradley Bekh²,Binder Elisabeth B.²⁶,Wahlestedt Claes³,Ressler Kerry J.¹²⁷

Affiliation:

1. Yerkes National Primate Research Center, Atlanta, GA 30329, USA.

2. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30329, USA.

3. Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

4. Department of Chemistry, The Scripps Research Institute—Scripps Florida, Jupiter, FL 33458, USA.

5. Molecular Therapeutics, The Scripps Research Institute—Scripps Florida, Jupiter, FL 33458, USA.

6. Max Planck Institute of Psychiatry, Munich 80804, Germany.

7. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Abstract

An agonist of the opioid receptor–like 1 protein may ameliorate the symptoms of posttraumatic stress disorder if given shortly after exposure to a traumatic event.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior

2. Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala

3. Regulation of Synaptic Plasticity Genes during Consolidation of Fear Conditioning

4. EARLY INTERVENTIONS FOR PTSD: A REVIEW

5. Fear extinction and BDNF: translating animal models of PTSD to the clinic

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