An NKG2D-Mediated Human Lymphoid Stress Surveillance Response with High Interindividual Variation

Author:

Shafi Seema1,Vantourout Pierre12,Wallace Graham3,Antoun Ayman4,Vaughan Robert56,Stanford Miles7,Hayday Adrian1268

Affiliation:

1. Peter Gorer Department of Immunobiology, King’s College London, London SE19 RT, UK.

2. London Research Institute, Cancer Research UK, London WC2A 3LY, UK.

3. School of Immunity and Infection, University of Birmingham, Birmingham BI5 2TT, UK.

4. School of Cancer Studies, University of Birmingham, Birmingham BI5 2TT, UK.

5. Clinical Transplantation Department, Guy’s Hospital, London SE19 RT, UK.

6. Medical Research Council Centre for Transplantation Biology, London SE19 RT, UK.

7. Ophthalmology Department, St Thomas’ Hospital, London SE1 7EH, UK.

8. Comprehensive Biomedical Research Centre of Guy’s and St Thomas’ Hospitals and King’s College London, London SE19 RT, UK.

Abstract

Humans mount lymphocyte stress surveillance responses to MICA, but they are individually tuned to optimal bandwidths.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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