Lost in Translation: Neuropsychiatric Drug Development

Author:

Becker Robert E.12,Greig Nigel H.2

Affiliation:

1. Aristea Translational Medicine Corporation, Freeport, ME 04078, USA.

2. Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Abstract

The sluggish pace of development of new drugs for neuropsychiatric diseases can be attributed in part to faulty clinical trial design.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference65 articles.

1. D. L. Sackett S. E. Strauss W. S. Richardson W. Rosenberg R. B. Haynes Evidence-Based Medicine: How to Practice and Teach EBM (Churchill Livingstone New York 2000).

2. Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models

3. Rating the Raters

4. Rating Rater Improvement

5. Problems Arising from the Generalising of Treatment Efficacy from Clinical Trials in Alzheimer??s Disease

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