Rapid Emergence of Protease Inhibitor Resistance in Hepatitis C Virus-Reference-Cited by-同舟云学术

Rapid Emergence of Protease Inhibitor Resistance in Hepatitis C Virus

Published:2010-05-05 Issue:30 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rong Libin¹²,Dahari Harel³,Ribeiro Ruy M.¹,Perelson Alan S.¹

Affiliation:

1. Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

2. Department of Mathematics and Statistics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA.

3. Department of Medicine, University of Illinois, Chicago, IL 60612, USA.

Abstract

Computational modeling suggests that the rapid emergence of resistance to drugs against hepatitis C virus is a result of preexisting resistant virus and potent suppression of wild-type virus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference65 articles.

1. Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection

2. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

3. Challenges and successes in developing new therapies for hepatitis C

4. The way forward in HCV treatment — finding the right path

5. The Hepatitis C Virus Life Cycle as a Target for New Antiviral Therapies

Cited by 320 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody;PLOS Pathogens;2024-04-18

2. Mathematical analysis of a multiscale hepatitis C virus infection model with two viral strains;Applied Mathematical Modelling;2024-01

3. Recent advancements in NS5B inhibitors (2011-2021): Structural insights, SAR studies and clinical status;Journal of Molecular Structure;2023-12

4. Combination Therapy with UV-4B and Molnupiravir Enhances SARS-CoV-2 Suppression;Viruses;2023-05-16

5. A Novel Approach to Develop New and Potent Inhibitors for the Simultaneous Inhibition of Protease and Helicase Activities of HCV NS3/4A Protease: A Computational Approach;Molecules;2023-01-29