Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1-Reference-Cited by-同舟云学术

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

Published:2011-12-14 Issue:113 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wu Ai-Luen¹,Kolumam Ganesh²,Stawicki Scott³,Chen Yongmei³,Li Jun⁴,Zavala-Solorio Jose²,Phamluong Khanhky¹,Feng Bo¹,Li Li⁵,Marsters Scot⁴,Kates Lance²,van Bruggen Nicholas²,Leabman Maya⁶,Wong Anne⁷,West David⁶,Stern Howard⁸,Luis Elizabeth⁹,Kim Hok Seon³,Yansura Daniel³,Peterson Andrew S.¹,Filvaroff Ellen⁴,Wu Yan³,Sonoda Junichiro¹

Affiliation:

1. Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.

2. Biomedical Imaging, Genentech Inc., South San Francisco, CA 94080, USA.

3. Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.

4. Molecular Oncology, Genentech Inc., South San Francisco, CA 94080, USA.

5. Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA.

6. Pharmacokinetic and Pharmacodynamic Sciences, Genentech Inc., South San Francisco, CA 94080, USA.

7. Assay and Automation Technology, Genentech Inc., South San Francisco, CA 94080, USA.

8. Pathology, Genentech Inc., South San Francisco, CA 94080, USA.

9. Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.

Abstract

Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by affecting brown adipose tissues.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference31 articles.

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2. FGF21 reloaded: challenges of a rapidly growing field

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4. Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

5. The Metabolic State of Diabetic Monkeys Is Regulated by Fibroblast Growth Factor-21

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