CD4 + T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy-Reference-Cited by-同舟云学术

CD4 + T Cell Autoimmunity to Hypocretin/Orexin and Cross-Reactivity to a 2009 H1N1 Influenza A Epitope in Narcolepsy

Published:2013-12-18 Issue:216 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

De la Herrán-Arita Alberto K.¹,Kornum Birgitte Rahbek¹²,Mahlios Josh¹,Jiang Wei³,Lin Ling¹,Hou Tieying³,Macaubas Claudia³,Einen Mali¹,Plazzi Giuseppe⁴,Crowe Catherine⁵,Newell Evan W.⁶,Davis Mark M.⁶,Mellins Elizabeth D.³⁶,Mignot Emmanuel¹⁶

Affiliation:

1. Center for Sleep Sciences and Medicine, Stanford School of Medicine, Palo Alto, CA 94304, USA.

2. Molecular Sleep Lab, Department of Diagnostics, and Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup Hospital, 2600 Glostrup, Denmark.

3. Department of Pediatrics, Stanford School of Medicine, Palo Alto, CA 94305, USA.

4. IRCCS Institute of Neurological Sciences and Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna 40123, Italy.

5. Mater Private Sleep Laboratory, Dublin 7, Ireland.

6. Program in Immunology, Stanford School of Medicine, Palo Alto, CA 94305, USA.

Abstract

Patients with narcolepsy carry CD4 + T cells that react to peptides from both the sleep-regulating neuropeptide hypocretin and a 2009 H1N1 influenza A protein.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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