Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier-Reference-Cited by-同舟云学术

Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier

Published:2013-05 Issue:183 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Couch Jessica A.¹,Yu Y. Joy²,Zhang Yin³,Tarrant Jacqueline M.¹,Fuji Reina N.¹,Meilandt William J.²,Solanoy Hilda²,Tong Raymond K.⁴,Hoyte Kwame⁵,Luk Wilman⁵,Lu Yanmei⁵,Gadkar Kapil¹,Prabhu Saileta¹,Ordonia Benjamin A.¹,Nguyen Quyen¹,Lin Yuwen¹,Lin Zhonghua⁶,Balazs Mercedesz⁶,Scearce-Levie Kimberly²,Ernst James A.⁴,Dennis Mark S.³,Watts Ryan J.²

Affiliation:

1. Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

2. Neurodegeneration Labs, Department of Neuroscience, Genentech Inc., South San Francisco, CA 94080, USA.

3. Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.

4. Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.

5. Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.

6. Translational Immunology, Genentech Inc., South San Francisco, CA 94080, USA.

Abstract

The safety of therapeutic bispecific antibodies that use TfR for delivery to the brain can be improved by reducing affinity for TfR and eliminating antibody effector function.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference31 articles.

1. Developing drugs that can cross the blood-brain barrier: applications to Alzheimer's disease

2. Macromolecular drug transport into the brain using targeted therapy

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4. Transferrin receptor on endothelium of brain capillaries

5. Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.

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