Glycosylations in the Globular Head of the Hemagglutinin Protein Modulate the Virulence and Antigenic Properties of the H1N1 Influenza Viruses-Reference-Cited by-同舟云学术

Glycosylations in the Globular Head of the Hemagglutinin Protein Modulate the Virulence and Antigenic Properties of the H1N1 Influenza Viruses

Published:2013-05-29 Issue:187 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Medina Rafael A.¹²³,Stertz Silke¹⁴,Manicassamy Balaji¹²⁵,Zimmermann Petra⁴,Sun Xiangjie⁶,Albrecht Randy A.¹²,Uusi-Kerttula Hanni³,Zagordi Osvaldo⁴,Belshe Robert B.⁷,Frey Sharon E.⁷,Tumpey Terrence M.⁶,García-Sastre Adolfo¹²⁸

Affiliation:

1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

2. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

3. Laboratory of Molecular Virology, Millennium Institute on Immunology and Immunotherapy, Centro de Investigaciones Médicas y División de Pediatría, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile.

4. Institute of Medical Virology, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland.

5. Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.

6. Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

7. Saint Louis University School of Medicine, Saint Louis University, St. Louis, MO 63104, USA.

8. Division of Infectious Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

Hemagglutinin glycosylations modulate the virulence and antigenicity of H1N1 influenza viruses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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