Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men-Reference-Cited by-同舟云学术

Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men

Published:2012-09-12 Issue:151 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Anderson Peter L.¹,Glidden David V.²,Liu Albert³,Buchbinder Susan²³,Lama Javier R.⁴⁵,Guanira Juan Vicente⁵,McMahan Vanessa⁶,Bushman Lane R.¹,Casapía Martín⁷,Montoya-Herrera Orlando⁸,Veloso Valdilea G.⁹,Mayer Kenneth H.¹⁰¹¹,Chariyalertsak Suwat¹²,Schechter Mauro¹³,Bekker Linda-Gail¹⁴,Kallás Esper Georges¹⁵¹⁶,Grant Robert M.²⁶,

Affiliation:

1. University of Colorado Denver, Aurora, CO 80045, USA.

2. University of California, San Francisco, San Francisco, CA 94143, USA.

3. HIV Research Section, San Francisco Department of Public Health, San Francisco, CA 94102, USA.

4. Investigaciones Medicas en Salud, Lima 14, Peru.

5. Asociación Civil Impacta Salud y Educación, Lima, Peru.

6. Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.

7. Asociación Civil Selva Amazónica, Iquitos, Maynas, Peru.

8. Fundación Ecuatoriana Equidad, Guayaquil-Guayas, Ecuador.

9. Instituto de Pesquisa Clinica Evandro Chagas, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro CEP 21040-900, Brazil.

10. Brown University, Providence, RI 02912, USA.

11. Fenway Institute, Fenway Health, Boston, MA 02215, USA.

12. Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

13. Projeto Praça Onze, Hospital Escola São Francisco de Assis, Universidade Federal do Rio de Janeiro, Rio de Janeiro CEP 20.210-030, Brazil.

14. Desmond Tutu HIV Centre and Department of Medicine, University of Cape Town, Cape Town 7925, South Africa.

15. Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, SP 05403-000, Brazil.

16. Instituto de Investigação em Imunologia, Cerqueira Cesar, São Paulo, SP CEP 05403-900, Brazil.

Abstract

PrEP drug concentrations associated with ≥90% reduction in HIV acquisition in men who have sex with men are achieved with daily dosing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference27 articles.

1. Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

2. UNAIDS 2010.

3. Elevated Risk for HIV Infection among Men Who Have Sex with Men in Low- and Middle-Income Countries 2000–2006: A Systematic Review

4. D. Donnell et al. paper presented at the 19th Conference on Retroviruses and Opportunistic Infections Seattle WA 5 to 8 March 2012.

5. Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women

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