Systematic Analysis of Breast Cancer Morphology Uncovers Stromal Features Associated with Survival

Author:

Beck Andrew H.12,Sangoi Ankur R.13,Leung Samuel4,Marinelli Robert J.5,Nielsen Torsten O.4,van de Vijver Marc J.6,West Robert B.1,van de Rijn Matt1,Koller Daphne7

Affiliation:

1. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Biomedical Informatics Training Program, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Department of Pathology, El Camino Hospital, Mountain View, CA 94040, USA.

4. Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, British Columbia V6H 3Z6, Canada.

5. Department of Biochemistry, Stanford University, Stanford, CA 94305, USA.

6. Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, Netherlands.

7. Department of Computer Science, Stanford University, Stanford, CA 94305, USA.

Abstract

Automated quantification of thousands of morphologic features in microscopic images of breast cancer allows the construction of a robust prognostic model.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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