Generation of Effector Memory T Cell–Based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination-Reference-Cited by-同舟云学术

Generation of Effector Memory T Cell–Based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination

Published:2013-09-25 Issue:204 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Li Adrienne V.¹²,Moon James J.¹³⁴,Abraham Wuhbet²,Suh Heikyung²⁵,Elkhader Jamal¹,Seidman Michael A.⁶,Yen Minmin¹,Im Eung-Jun⁷⁸,Foley Maria H.¹²,Barouch Dan H.⁷⁸,Irvine Darrell J.¹²³⁵⁷

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

2. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

3. Department of Materials Science and Engineering, MIT, Cambridge, MA 02139, USA.

4. Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA.

5. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

6. Department of Pathology and Laboratory Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

7. Ragon Institute of MGH, MIT and Harvard, Boston, MA 02139, USA.

8. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Abstract

A lipid nanocapsule vaccine promotes cross-presentation of antigen with enhanced draining lymph node delivery to elicit an effector memory CD8 + T cell response.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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