Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy

Author:

Ji Minbiao1,Orringer Daniel A.2,Freudiger Christian W.1,Ramkissoon Shakti34,Liu Xiaohui5,Lau Darryl2,Golby Alexandra J.56,Norton Isaiah5,Hayashi Marika4,Agar Nathalie Y. R.56,Young Geoffrey S.6,Spino Cathie7,Santagata Sandro3,Camelo-Piragua Sandra8,Ligon Keith L.349,Sagher Oren2,Xie X. Sunney1

Affiliation:

1. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

2. Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.

3. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

5. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

6. Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

7. Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.

8. Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

9. Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Stimulated Raman scattering microscopy provides a rapid, label-free means of detecting tumor infiltration of brain tissue ex vivo and in vivo.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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