Angiotensin-Converting Enzyme–Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4

Angiotensin-Converting Enzyme–Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin-4–Deficient Mice

Published:2013-05 Issue:183 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Huang Jianbin¹,Yamashiro Yoshito¹,Papke Christina L.¹,Ikeda Yuichi²³,Lin Yanling¹,Patel Miteshkumar¹,Inagami Tadashi⁴,Le Victoria P.⁵,Wagenseil Jessica E.⁵,Yanagisawa Hiromi¹

Affiliation:

1. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390–9148, USA.

2. Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390–9148, USA.

3. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390–9050, USA.

4. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37235, USA.

5. Department of Biomedical Engineering, St. Louis University, St. Louis, MO 63103–2010, USA.

Abstract

Up-regulation of angiotensin-converting enzyme in the aortic wall causes aneurysms in fibulin-4–deficient mice, which can be prevented by losartan or captopril.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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