Host Alloreactive Memory T Cells Influence Tolerance to Kidney Allografts in Nonhuman Primates

Author:

Nadazdin Ognjenka1,Boskovic Svjetlan1,Murakami Toru1,Tocco Georges1,Smith Rex-Neal2,Colvin Robert B.2,Sachs David H.3,Allan James1,Madsen Joren C.1,Kawai Tatsuo1,Cosimi A. Benedict1,Benichou Gilles1

Affiliation:

1. Transplant Center, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

2. Pathology Department, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

3. Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA 02129, USA.

Abstract

Only nonhuman primates with low frequencies of donor-specific memory T cells develop tolerance and accept allogeneic kidney transplants.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. Mixed allogeneic chimerism as an approach to transplantation tolerance

2. MIXED CHIMERISM AS AN APPROACH FOR THE INDUCTION OF TRANSPLANTATION TOLERANCE1

3. Bone marrow transplantation as a means of inducing tolerance.;Sykes M.;Semin. Immunol.,1990

4. CTLA4-Ig PLUS BONE MARROW INDUCES LONG-TERM ALLOGRAFT SURVIVAL AND DONOR-SPECIFIC UNRESPONSIVENESS IN THE MURINE MODEL

5. Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.;Lakkis F. G.;J. Immunol.,1997

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