Learning to identify CNS drug action and efficacy using multistudy fMRI data-Reference-Cited by-同舟云学术

Learning to identify CNS drug action and efficacy using multistudy fMRI data

Published:2015-02-11 Issue:274 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Duff Eugene P.¹,Vennart William²,Wise Richard G.³,Howard Matthew A.⁴,Harris Richard E.⁵,Lee Michael¹,Wartolowska Karolina¹,Wanigasekera Vishvarani¹,Wilson Frederick J.²,Whitlock Mark²,Tracey Irene¹,Woolrich Mark W.¹⁶,Smith Stephen M.¹

Affiliation:

1. Functional Magnetic Resonance Imaging of the Brain Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX39DU, UK.

2. Pfizer Ltd., Cambridge CB21 6GS, UK.

3. Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff CF10 3AT, UK.

4. Department of Neuroimaging, Institute of Psychiatry, King’s College, London SE58AF, UK.

5. Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48105, USA.

6. Oxford University Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford OX3 7JX, UK.

Abstract

Existing functional brain imaging data sets were used to identify neural signatures that confirm pharmacological action and predict clinical efficacy of test compounds.

Funder

Wellcome Trust

NIHR (National Institute for Health Research)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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