Long-Term Persistence of a Polyclonal T Cell Repertoire After Gene Therapy for X-Linked Severe Combined Immunodeficiency-Reference-Cited by-同舟云学术

Long-Term Persistence of a Polyclonal T Cell Repertoire After Gene Therapy for X-Linked Severe Combined Immunodeficiency

Published:2011-08-24 Issue:97 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Gaspar H. Bobby¹²,Cooray Samantha¹²,Gilmour Kimberly C.¹²,Parsley Kathryn L.¹²,Adams Stuart³,Howe Steven J.¹,Al Ghonaium Abdulaziz⁴,Bayford Jinhua¹²,Brown Lucinda¹²,Davies E. Graham¹²,Kinnon Christine¹,Thrasher Adrian J.¹²

Affiliation:

1. Centre for Immunodeficiency, Molecular Immunology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK.

2. Department of Clinical Immunology, Great Ormond Street Hospital NHS Trust, London WC1N 3JH, UK.

3. Department of Bone Marrow Transplantation, Great Ormond Street Hospital NHS Trust, London WC1N 3JH, UK.

4. Department of Paediatric Allergy/Immunology, King Faisal Specialist Hospital and Research Centre, Riyadh 1121, Saudi Arabia.

Abstract

Gene therapy results in long-term persistence of T cells in immunodeficient patients.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference24 articles.

1. Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

2. Severe combined immunodeficiency. A model disease for molecular immunology and therapy

3. Cytokines and immunodeficiency diseases: critical roles of the gammac-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways

4. Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968–99

5. Hematopoietic Stem-Cell Transplantation for the Treatment of Severe Combined Immunodeficiency

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