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The Emergence of Genome-Based Drug Repositioning

  • Published:2011-08-17 Issue:96 Volume:3 Page:
  • ISSN:1946-6234
  • Container-title:Science Translational Medicine
  • language:en
  • Short-container-title:Sci. Transl. Med.

Author:

Lussier Yves A.123,Chen James L.4

Affiliation:

1. Section of Genetic Medicine, University of Chicago, Chicago, IL 60637, USA.

2. Institute of Genomics and Systems Biology, University of Chicago, Chicago, IL 60637, USA.

3. Computational Institute, University of Chicago, Chicago, IL 60637, USA.

4. Section of Hematology/Oncology of the Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

Abstract

Genome-wide methods of mRNA signature analyses permit the high-throughput evaluation of medications for drug repurposing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference24 articles.

1. Reductionism and complexity in molecular biology

2. Discovery and preclinical validation of drug indications using compendia of public gene expression data;Sirota M.;Sci. Transl. Med.,2011

3. Repurposing with a Difference

4. Computational repositioning of the anticonvulstant topiramate for inflammatory bowel disease;Dudley J. T.;Sci. Transl. Med.,2011

5. Central Dogma of Molecular Biology

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