Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients-Reference-Cited by-同舟云学术

Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients

Published:2011-03-30 Issue:76 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Jons Christian¹,O-Uchi Jin²,Moss Arthur J.¹,Reumann Matthias³,Rice John J.³,Goldenberg Ilan³,Zareba Wojciech¹,Wilde Arthur A. M.⁴,Shimizu Wataru⁵,Kanters Jorgen K.⁶⁷,McNitt Scott¹,Hofman Nynke⁸,Robinson Jennifer L.¹,Lopes Coeli M. B.²

Affiliation:

1. Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

2. Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

3. Functional Genomics and Systems Biology Group, IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA.

4. Heart Failure Research Centre, Department of Cardiology, Academic Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, Netherlands.

5. National Cardiovascular Center, Suita 565-8565, Japan.

6. Gentofte University Hospital, DK 2820 Copenhagen, Denmark.

7. Danish National Research Foundation Center for Cardiac Arrhythmias, DK 2200 Copenhagen, Denmark.

8. Department of Clinical Genetics, Academic Medical Centre, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands.

Abstract

Mutations that slow the opening of potassium channels in the heart can predict risk for long QT syndrome, a heart arrhythmia that can cause sudden death.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference57 articles.

1. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

2. Risk Stratification in the Long-QT Syndrome

3. Long QT Syndrome in Adults

4. Risk of Aborted Cardiac Arrest or Sudden Cardiac Death During Adolescence in the Long-QT Syndrome

5. Risk Factors for Aborted Cardiac Arrest and Sudden Cardiac Death in Children With the Congenital Long-QT Syndrome

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